Chinese skullcap is one of the 50 fundamental herbs of traditional chinese medicine. Scutellaria baicalensis is an herb used in traditional chinese medicine to treat a variety of conditions including epilepsy, hepatitis, infections, and cancer. Treating liver disease by chinese medicine has become the focus of current research. Don lamiaceae is widely used in traditional medicine in. The university of minnesota is an equal opportunity educator and employer. About 51% of these are herbal extract, 21% are other extracts, and 0% are other healthcare supply. We dig bareroot plants from our outdoor beds and ship them aprilmay and october. A chinese herb that belongs to a group of herbs named scutellaria scullcap or skullcap. Phytotoxic neoclerodane diterpenoids from the aerial parts of scutellaria barbata. Antileukemic activity of the chemical constituents from. Scutellaria barbata herb uses, benefits, cures, side effects. Scutellaria baicalensis is used in traditional medicine to treat many medical conditions. Don is an accepted name this name is the accepted name of a species in the genus scutellaria family lamiaceae.
Mint lamiaceae hardy to zones 7 to 10, otherwise grown as an annual barbat skullcap, banzhilian herbaceous perennial to 18 inches. Neoclerodane diterpenoids from scutellaria barbata with. May 30, 2011 hello, md anderson and many others are on a phase 2 trial of this scutellaria barbata herb. Scutellaria incana, commonly called skullcap, is a missouri native wildflower that occurs in open woods, clearings, on slopes and along streams in the northcentral and ozark regions of the state. Hello, md anderson and many others are on a phase 2 trial of this scutellaria barbata herb. C524947000 scutellaria barbata extract searchable synonyms, formulas, resource links, and other chemical information. Don references edit prodromus florae nepalensis, sive enumeratio vegetabilium, quae in itinere per nepaliam proprie dictam et rgiones conterminas, ann.
It is clinically remarkable for reducing inflammation in dermatologic conditions and should be considered an important herb in formulations for treating acne and other skin conditions. Male transgenic adenocarcinoma mouse prostate tramp mice at 9 weeks were randomly divided into four groups and given daily oral feedings of 8, 16, or 32 mg sb or sterilized water. Plants profile for scutellaria parvula small skullcap. Scutellaria baicalensis, or scute, is considered specific in tcm for clearing damp heat, a category of diagnosis in which acne may commonly fall. Clerodane diterpenoids from scutellaria barbata nguyen, van hung. It has also been shown to be safe in a clinical trial of women with advanced breast cancer, and to inhibit cell proliferation and induce ca. The record derives from wcsp data supplied on 20120323 which reports it as an accepted name record 188943 with original publication details. Scutellaria barbata is a perennial herb prevalent in korea and southern china. However, the effects of sbf on impaired learning and memory. Hi melinda, thank you for mentioning the scutellaria barbata. All structured data from the file and property namespaces is available under the creative commons cc0 license. This paper summarized the application of scutellaria barbata in liver disease. Huangqin, radix scutellariae, is the dry roots of scutellaria baicalensis georgi lamiaceae, which is collected in spring and fall. It has been traditionally used in folk medicine as antiinflammatory and antitumor agents 11, 12.
Scutellaria barbata herb advanced breast cancer inspire. Bioassayguided fractionation was conducted on an etoacsoluble extract of the whole plants of scutellaria barbata, monitored by inhibition of epsteinbarr virus ebv lytic replication. Scutellaria species, barbed skullcap, skullcap scutellaria. Scutellaria barbata memorial sloan kettering cancer center. Mint lamiaceae hardy to zones 7 to 10 barbat skullcap, banzhilian herbaceous perennial to 18 inches. How scutellaria barbata is effective for various diseases is listed in repertory format. We are among the few still employing this production method, which is labor intensive but plantfriendly. Hangying li, wenjun wei, kailiang ma, jieyao zhang, ya li, kun gao, bioactivity guided the isolation of extracts from the aerial parts scutellaria barbata d. In china through the centuries, the whole herb of s. Scutellaria baicalensis memorial sloan kettering cancer center. Scutellaria barbata is an herb that grows in korea and southern china. Scutellaria barbata sb has been used in chinese medicine to treat various cancers.
Bzl101 is an aqueous extract from the scutellaria barbata plant shown to have anticancer properties in a variety of human cancers. This herb really grows well for us and i think it is somewhat stouter and tougher than most of the other species of skullcap. Bzl101, a phytochemical extract from the scutellaria barbata. The structures of 1 were elucidated by analysis of their nmr. The structures of 1 were elucidated by analysis of their nmr and ms. Nonsmall cell lung cancer nsclc is the most ordinary type of lung cancer which leads to of all cancer deaths.
Scutellaria barbata barbed skullcap pfaf plant database. Don, have been shown to alleviate fever, inflammation, peroxidation, as well as improve memory deficits and neuroendocrine and abnormal free radical changes in ovariectomized rats 79. The polysaccharide is isolated from the scutellaria barbara and furtherpurified by deaecellulose52 column chromatography and sephadex g100column chromatography. In order to determine its efficacy on human reproductive cancers, we assessed the responses of two human breast cancer cell lines, estrogen sensitive mcf7 and estrogen insensitive mdamb231, and of two human prostate cancer cell. It is in flower from june to august, and the seeds ripen from july to september.
Scutellaria barbata flavonoids alleviate memory deficits and. Scutellaria incana hoary skullcap prairie moon nursery. Antileukemic activity of the chemical constituents from scutellaria. The scutellaria species lamiaceae is used as a source of flavonoids to treat a variety of diseases in traditional medicine. Don, a perennial herb belonging to the family lamiaceae, is widely distributed throughout china and korea. The plants database includes the following 45 species of scutellaria. Scutellaria barbata as commonly used in clinical medicine,has been widely used in the treatmentrelated liver disease. However, nsclc is relatively resistant to the above therapeutic strategies, resulting in a rather low 20% 5year. The purified polysaccharide is shown to bechemically homogeneous by means of agarose elecrophoreris,celluloseacetatemembrane electrophcresis,glassfilter paper eectrophoresis and gelfiltration chromatography. Baikal skullcap scutellaria baicalensis plant profiler. The cytotoxic properties of total methanol extract of. Uses, benefits, cures, side effects, nutrients in scutellaria barbata. It is in flower from may to july, and the seeds ripen from june to august. This study investigated the effects of sb on prostate cancer prevention.
An extract of this plant, bzl101, has been shown to have anticancer properties in a variety of human cancers. Scutellaria barbata herb uses, benefits, cures, side. It has also been shown to be safe in a clinical trial of women with advanced breast cancer, and to inhibit cell proliferation and induce cancer cell death. Clerodane diterpenoids from scutellaria barbata novel antioxidant neo. The species is hermaphrodite has both male and female organs. A wide variety of scutellaria barbata extract options are available to you, such as part, packaging, and form. New norditerpenoid alkaloids from scutellaria barbata with cytotoxic activities, natural product.
This study aimed to investigate the inhibitory effects of the total flavones in s. Stub this article has been rated as stubclass on the projects quality scale. Don references edit prodromus florae nepalensis, sive enumeratio vegetabilium, quae in itinere per nepaliam proprie dictam et. Comparative genome analysis of scutellaria baicalensis and scutellaria barbata reveals the evolution of active flavonoid biosynthesis preprint pdf available february 2020 with 65 reads. Using the chinese herb scutellaria barbata against extensively drug. Pdf is not rendering correctly, you can download the pdf file here. Click below on a thumbnail map or name for species profiles. New norditerpenoid alkaloids from scutellaria barbata with cytotoxic activities. The lightly toothed leaves are somewhat lanceshaped or triangular and up to about 3 centimeters long. Small, twolipped, purplish blue flowers typical mint family appear in branching, loose racemes in summer. It is officially listed in the chinese pharmacopoeia and is one of the most widely used chinese herbal medicines against bacterial infections of the respiratory and the gastrointestinal tract.
Studies on its potential anticancer effects are underway. This article is within the scope of wikiproject plants, a collaborative effort to improve the coverage of plants and botany on wikipedia. Don has been used as a traditional chinese medicine for antitumor and antiinflammatory. Scutellaria barbata flavonoids sbf, which are isolated from the aerial parts of s. Scutellaria baicalensis an overview sciencedirect topics.
The results from phase 1 were extremely impressive. However, there were just a few investigations about s. Skullcap, barbat scutellaria barbata, packet of 50 seeds. Scutellaria is a genus of hardy perennial plants that range in height from 10 to 90 cm the ones that are grown in gardens tend to be low growing and have a spreading nature, making them ideal for use in rock gardens. A very isolated genus with unsatisfactory traditional divisions. The aim of the present study was to investigate the effects of scutellaria barbata flavonoids sbf on memory impairment and neuronal injury induced by amyloid beta protein 2535 in combination with aluminum trichloride alcl3 and recombinant human transforming growth factor. The plants database includes the following 3 subspecies of scutellaria parvula. Pdf abstract ethnopharmacological relevance experiencebased herbal medicine as a complementary to modern western medicine has triggered an array of. Pdf from scutellaria barbata to bzl101 in cancer patients. Pdf enhanced anticancer effects of scutellaria barbata d.
Liver diseases threat to human health,affecting the quality of peoples lives. Scutellaria is a genus of hardy perennial plants that range in height from 10 to 90 cm the ones that are grown in gardens tend to be low growing and have a spreading. Most studies have been conducted in the lab rather than in humans. Click below on a thumbnail map or name for subspecies profiles. Application of scutellaria barbata in liver diseases.
Names of scutellaria barbata in various languages of the world are also given. It often is used in combination with other botanicals such as pcspes and shosaikoto. Scutellaria barbata flavonoids alleviate memory deficits. It is used along with other herbs in traditional chinese medicine to treat bacterial infections, hepatitis, and tumors, and is also used as a diuretic. Browse pictures and read growth cultivation information about scutellaria species, barbed skullcap, skullcap scutellaria barbata supplied by member gardeners in.
Bzl101, a phytochemical extract from the scutellaria. In order to determine its efficacy on human reproductive cancers, we assessed the responses of two human breast cancer cell lines, estrogen sensitive mcf7 and estrogen insensitive mdamb231, and of two human. At present, cytotoxic chemotherapy, surgical resection, radiation, and photodynamic therapy are the main strategies for nsclc treatment. Pdf functional components in scutellaria barbata d. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks. It can grow in semishade light woodland or no shade. Don to discover neoclerodane diterpenoids with potent phytotoxic activity.
Skullcap, barbat scutellaria barbata potted plant, organic. This page was last edited on 16 december 2019, at 19. Scutellaria baicalensis, known as chinese skullcap or baikal skullcap, is native to the mountains of eastern asia. Of the 30 herbs tested, only scutellaria barbata demonstrated 100% in vitro activity against xdrab. Various chromatographic separations of the aerial parts of scutellaria barbata afforded two new neoclerodane diterpenoids, scutebatas s and t 1 and 2, along with scutebata d 3. Both the root and the aboveground part of scutellaria barbata have been used to make herbal medicines. Anticancer activity and mechanism of scutellaria barbata.
In spite of many reports about the cytotoxic and antitumor effects of some species of this genus, anticancer researches on one of the iranian species s. Stems erect, 123555 cm tall, glabrous or sparsely appressed pubescent upward. Twentysix neoclerodane diterpenoids were isolated, of which are new 1, scutolides al and previously known 1426. Don according to bioactivitydirected isolation and online identification for the chemical constituents. It should not be confused with scutellaria baicalensis. It is a perennial herb generally reaching up to 35 centimeters tall, sometimes taller.
Chinese medicinal herb scutellaria barbata modulates. Treatment of lung cancer, digestive system cancers, hepatoma, breast cancer, and chorioepithelioma by s. Clinical uses of scutellaria barbata formulae in cancer. In one study, 125gl of scutellaria barbata inhibited the dna damage in lymphocytes caused by the total particle material extracted from cigarette tar. In this work, eight compounds were isolated from s. Aug 15, 2010 bzl101 is an aqueous extract from the scutellaria barbata plant shown to have anticancer properties in a variety of human cancers. From scutellaria barbata to bzl101 in cancer patients. They arrive to you dormant, with little to no topgrowth bareroot, packed in peat moss. The species is hermaphrodite has both male and female organs and is pollinated by bees, flies. Pdf the objectives of this study were to determine the variety and amount of various functional components in scutellaria barbata d. Scutellaria baicalensis memorial sloan kettering cancer. Scutellaria barbata name synonyms scutellaria adenophylla miq. Files are available under licenses specified on their description page.